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"Graphene-based nanomaterials are being paired with common over-the-counter drugs like ibuprofen. "Innovations" like these are becoming increasingly important in the era of biodigital convergence, where medicine, advanced materials, and digital technologies are rapidly merging the physical and digital world..
This paper states that graphene oxide and its modified forms are being explored as smart drug-delivery carriers for ibuprofen because their ultra-thin, high-surface-area sheets can hold large amounts of the drug and release it in a controlled way inside the body. Their surfaces contain oxygen-based chemical groups that make them water-dispersible and allow ibuprofen to attach either between the layers or along the sheet edges through hydrophobic and π–π interactions. According to the authors this lets graphene oxide protect ibuprofen as it passes through the harsh, acidic environment of the stomach—where the drug normally causes irritation—and then release much more of it later in the intestine, where absorption happens. By tuning the surface chemistry of graphene (such as adding sulfonic or carboxyl groups), researchers can control how tightly ibuprofen binds and how quickly it is released, making graphene-based nanomaterials promising candidates for "safer," more efficient ibuprofen delivery.
Provided below is a section-by-section overview of the paper "Comparative Study of Various Graphene Oxide Structures as Efficient Drug Release Systems for Ibuprofen""

https://www.mdpi.com/2673-9623/2/2/6
!!!!! "Graphene-based nanomaterials are being paired with common over-the-counter drugs like ibuprofen. "Innovations" like these are becoming increasingly important in the era of biodigital convergence, where medicine, advanced materials, and digital technologies are rapidly merging the physical and digital world.. 👇 This paper states that graphene oxide and its modified forms are being explored as smart drug-delivery carriers for ibuprofen because their ultra-thin, high-surface-area sheets can hold large amounts of the drug and release it in a controlled way inside the body. Their surfaces contain oxygen-based chemical groups that make them water-dispersible and allow ibuprofen to attach either between the layers or along the sheet edges through hydrophobic and π–π interactions. According to the authors this lets graphene oxide protect ibuprofen as it passes through the harsh, acidic environment of the stomach—where the drug normally causes irritation—and then release much more of it later in the intestine, where absorption happens. By tuning the surface chemistry of graphene (such as adding sulfonic or carboxyl groups), researchers can control how tightly ibuprofen binds and how quickly it is released, making graphene-based nanomaterials promising candidates for "safer," more efficient ibuprofen delivery. Provided below is a section-by-section overview of the paper "Comparative Study of Various Graphene Oxide Structures as Efficient Drug Release Systems for Ibuprofen"" https://www.mdpi.com/2673-9623/2/2/6
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Comparative Study of Various Graphene Oxide Structures as Efficient Drug Release Systems for Ibuprofen
Ibuprofen is a non-steroidal, anti-inflammatory drug that is widely prescribed for its analgesic, antipyretic, and anti-inflammatory actions to treat pain, symptoms of rheumatoid arthritis and fever, but it is also known to cause stomach-related side effects. The development of efficient drug delivery systems for this compound to prevent these side effects is hampered by its poor water solubility. In this work, we show that graphite oxide and its derivatives have great potential as effective drug delivery systems not only to overcome side effects but also to increase the short biological half-life of ibuprofen. We studied the adsorption capacity of graphite oxide and carboxylated and sulfonated graphene oxide for this drug and its release in simulated gastric and intestinal fluid. The obtained compounds were characterized by X-ray diffraction, thermogravimetric analysis and Fourier transform infrared spectroscopy. DFT calculations were conducted to elucidate the Ibuprofen/host interactions, to establish which properties of these carbon nanomaterials control the loading and release, as well as to provide a better understanding of the orientation of the drug molecules on the single-layer GO.
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